Longevity Research Landscape

From a scientific standpoint, longevity involves understanding and addressing the fundamental mechanisms of aging at the molecular and cellular levels. This approach seeks to mitigate age-related diseases and extend health span by targeting key factors like NAD+ levels and Sirtuin activation. In the pursuit of slowing or reversing the aging process, there are 10 areas of research that are adding to our understanding of NAD+ optimization. Our team is plugged into the global network of scientists leading this charge.

1. Epigenetics: Epigenetic modifications, such as DNA methylation and histone modifications, can influence gene expression and aging. Researchers investigate how epigenetic changes can be manipulated or reversed to promote longevity.
   
   
2. Caloric Restriction/Fasting Mimicking Diets: Caloric restriction, or reducing calorie intake without malnutrition, has been shown to extend lifespan in various organisms. Scientists explore the mechanisms through which caloric restriction affects metabolism and aging, offering insights into dietary interventions for longevity.
   
   
3. Mitochondrial Health: Mitochondria play a crucial role in energy production and oxidative stress. Research into enhancing mitochondrial function and reducing oxidative damage is a vital aspect of longevity studies.
   
   
4. Biological Clocks: Biological clocks, such as the circadian rhythm and the epigenetic clock, are associated with aging. Scientists investigate how optimizing these clocks can influence longevity.
   
   
5. Genetic Variability: Genetic factors strongly influence an individual’s susceptibility to age-related diseases and longevity. Identifying genetic markers associated with longevity and studying centenarians’ genetics are ongoing research areas.
   
   
6. Senescence and Senolytics: Cellular senescence, where cells lose their ability to divide and function properly, is linked to aging and age-related diseases.
   
   
7. Telomere Length and Telomerase Activity: Shortened telomeres are associated with cellular senescence and age-related diseases, and understanding how to preserve or lengthen telomeres is a key focus in longevity research.
   
   
8. Interactions with the Microbiome: The gut microbiome’s influence on health and aging is gaining attention. Understanding how the microbiome impacts longevity and vice versa is a growing field of research.
   
   
9. Environmental Factors: Beyond genetics, environmental factors like pollution, radiation, and lifestyle choices (e.g., smoking, physical activity, diet) have significant effects on longevity and are essential considerations in longevity studies.
   
   
10. Hormonal Regulation: Hormones like growth hormone, insulin-like growth factor 1 (IGF-1), and sex hormones can impact aging and longevity. Balancing hormone levels through interventions like hormone replacement therapy is an area of interest.